The β Turn as a Selectivity Switch: βI or βII′? That Is the Question | Zendy

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The β Turn as a Selectivity Switch: βI or βII′? That Is the Question

Author(s) -

Müller Gerhard

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199627671

Subject(s) - turn (biochemistry) , selectivity , chemistry , molecular switch , nanotechnology , combinatorial chemistry , materials science , organic chemistry , catalysis , molecule , biochemistry

In the design of peptide‐based drugs the β turn has been promoted to a design principle in recent years. In research on antiadhesive RGD mimetics, receptor selectivity has been shown to be encoded in the β‐turn type within cyclic peptides of type 1 having an identical lead sequence. Switching the turn type from βII′ to βI inverts the selectivity profile so that a compound originally with antithrombotic activity becomes an antimetastatic agent.

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