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The β Turn as a Selectivity Switch: βI or βII′? That Is the Question
Author(s) -
Müller Gerhard
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199627671
Subject(s) - turn (biochemistry) , selectivity , chemistry , molecular switch , nanotechnology , combinatorial chemistry , materials science , organic chemistry , catalysis , molecule , biochemistry
In the design of peptide‐based drugs the β turn has been promoted to a design principle in recent years. In research on antiadhesive RGD mimetics, receptor selectivity has been shown to be encoded in the β‐turn type within cyclic peptides of type 1 having an identical lead sequence. Switching the turn type from βII′ to βI inverts the selectivity profile so that a compound originally with antithrombotic activity becomes an antimetastatic agent.