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Catalytic Antibodies as Probes of Evolution: Modeling of a Primordial Glycosidase
Author(s) -
Shabat Doron,
Sinha Subhash C.,
Reymond JeanLouis,
Keinan Ehud
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199626281
Subject(s) - glycosidic bond , complementarity (molecular biology) , catalysis , chemistry , cleavage (geology) , hydrolysis , glycoside hydrolase , stereochemistry , combinatorial chemistry , enzyme , organic chemistry , materials science , biology , genetics , fracture (geology) , composite material
The hydrolysis of unactivated cyclic ketals such as 1 can be catalyzed by antibodies raised against the transition state analog 2 . This transformation is closely related to the cleavage of the glycosidic bond. The observed catalysis is triggered more by electrostatic complementarity to the transition state than by shape complementarity.