Catalytic Antibodies as Probes of Evolution: Modeling of a Primordial Glycosidase | Zendy

Shabat Doron | Zendy; Sinha Subhash C. | Zendy; Reymond JeanLouis | Zendy; Keinan Ehud | Zendy

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Catalytic Antibodies as Probes of Evolution: Modeling of a Primordial Glycosidase

Author(s) -

Shabat Doron,

Sinha Subhash C.,

Reymond JeanLouis,

Keinan Ehud

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199626281

Subject(s) - glycosidic bond , complementarity (molecular biology) , catalysis , chemistry , cleavage (geology) , hydrolysis , glycoside hydrolase , stereochemistry , combinatorial chemistry , enzyme , organic chemistry , materials science , biology , genetics , fracture (geology) , composite material

The hydrolysis of unactivated cyclic ketals such as 1 can be catalyzed by antibodies raised against the transition state analog 2 . This transformation is closely related to the cleavage of the glycosidic bond. The observed catalysis is triggered more by electrostatic complementarity to the transition state than by shape complementarity.

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