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Orthogonal Glycosylation Strategy for Rapid Assembly of Oligosaccharides on a Polymer Support
Author(s) -
Ito Yukishige,
Kanie Osamu,
Ogawa Tomoya
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199625101
Subject(s) - glycoconjugate , glycosylation , oligosaccharide , chemistry , polymer , glycoprotein , combinatorial chemistry , biochemistry , chromatography , organic chemistry
Only a single purification step is required to isolate the glycoconjugate‐related oligosaccharides prepared by a new strategy, which is shown schematically below. Prior to purification the support‐bound oligosaccharide, which is labeled with a hydrophobic tag, is cleaved from the polymeric support and deprotected.