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An Approach to Epothilones Based on Olefin Metathesis
Author(s) -
Nicolaou K. C.,
He Yun,
Vourloumis Dionisios,
Vallberg Hans,
Yang Zhen
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199623991
Subject(s) - epothilones , olefin metathesis , metathesis , ring closing metathesis , chemistry , salt metathesis reaction , ring (chemistry) , combinatorial chemistry , computer science , stereochemistry , organic chemistry , polymerization , polymer
The same mechanism as taxol but a completely different, simpler structure is displayed by the recently described epothilones A and B. These features immediately attracted the attention of synthetic chemists. An approach to the macrocyclic framework of the epothilones has now been devised through use of ring‐closing metathesis with the Grubbs catalyst [RuCl 2 (CHPh){P(C 6 H 11 ) 3 } 2 ].