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Reductive Carbon–Sulfur Bond Cleavage: A Simple Pathway to Nonstabilized (Lithiomethyl)amines
Author(s) -
Strohmann Carsten,
Abele Bors Cajus
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199623781
Subject(s) - chemistry , bond cleavage , sulfur , cleavage (geology) , tin , lithium (medication) , organic chemistry , combinatorial chemistry , catalysis , materials science , medicine , fracture (geology) , composite material , endocrinology
Compounds with the structural element ‐CH 2 NR 2 are easily accessible from (phenylthiomethyl)amines by reductive CS bond cleavage and subsequent addition or substitution (see below). One advantage of this shorter method than tin–lithium exchange is the ready availability of the starting materials, which need not be purified by chromatography.