Premium
A Catalyst‐Specific, Stereocontrolled Ring‐Closing Metathesis
Author(s) -
Huwe Christoph M.,
Velder Janna,
Blechert Siegfried
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199623761
Subject(s) - pyrrolidine , metathesis , catalysis , ring closing metathesis , carbene , chemistry , derivative (finance) , ring (chemistry) , stereochemistry , salt metathesis reaction , closing (real estate) , medicinal chemistry , combinatorial chemistry , organic chemistry , polymerization , business , finance , polymer
The catalyst decides whether the syn or anti product is formed! In the cyclization of 1 , the ring‐closing metathesis of two double bonds that are located at a chiral and a prochiral center leads to the α,α′‐disubstituted pyrrolidine derivative 2 with viable diastereoselectivity. Tfa = trifluoroacetyl, [Ru] and [Mo] = Ru‐ and Mo‐carbene complexes, respectively.