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Catalytic, Enantioselective Addition of Allylsilanes to Aldehydes: Generation of a Novel, Reactive Ti IV Complex from TiF 4
Author(s) -
Gauthier Donald R.,
Carreira Erick M.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199623631
Subject(s) - enantioselective synthesis , reactivity (psychology) , catalysis , reagent , chemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , medicine , alternative medicine , pathology
Unique reactivity is shown by the fluorotitanium complex obtained from TiF 4 and 1,1′‐bi‐2‐naphthol. It is more reactive than the chloro‐, bromo‐, and alkoxytitanium complexes previously employed and catalyzes the enantioselective additions of allyltrimethylsilane to aldehydes [Eq. (a)], providing an alternative to known methods involving the corresponding organotin reagents.