Catalytic, Enantioselective Addition of Allylsilanes to Aldehydes: Generation of a Novel, Reactive Ti IV  Complex from TiF 4 | Zendy

Gauthier Donald R. | Zendy; Carreira Erick M. | Zendy

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Catalytic, Enantioselective Addition of Allylsilanes to Aldehydes: Generation of a Novel, Reactive Ti IV Complex from TiF 4

Author(s) -

Gauthier Donald R.,

Carreira Erick M.

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199623631

Subject(s) - enantioselective synthesis , reactivity (psychology) , catalysis , reagent , chemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , medicine , alternative medicine , pathology

Unique reactivity is shown by the fluorotitanium complex obtained from TiF 4 and 1,1′‐bi‐2‐naphthol. It is more reactive than the chloro‐, bromo‐, and alkoxytitanium complexes previously employed and catalyzes the enantioselective additions of allyltrimethylsilane to aldehydes [Eq. (a)], providing an alternative to known methods involving the corresponding organotin reagents.

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