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Chemoenzymatic Synthesis of a Sialylated Undecasaccharide–Asparagine Conjugate
Author(s) -
Unverzagt Carlo
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199623501
Subject(s) - conjugate , asparagine , chemistry , enzyme , stereochemistry , biochemistry , combinatorial chemistry , mathematics , mathematical analysis
A partial structure of many glycoproteins , the complex undecasaccharide–asparagine conjugate 1 was obtained for the first time by total synthesis. Crucial to the synthesis was a combination of modern chemical and enzymatic methods, which reduced the overall number of steps and allowed efficient deprotonation.