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Stereoselective Synthesis of Steroids with the Heck Reaction
Author(s) -
Tietze Lutz F.,
Nöbel Thomas,
Spescha Maurus
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199622591
Subject(s) - indene , heck reaction , stereoselectivity , bromobenzene , chemistry , derivative (finance) , benzene , organic chemistry , stereochemistry , palladium , catalysis , financial economics , economics
By means of a double Heck reaction the pharmacologically interesting estrapentaene 3 can be synthesized regio‐ and stereoselectively from (Z)‐(2‐bromoethenyl)‐bromobenzene ( 1 ) and the indene derivative 2 . A variety of novel steroids can be obtained by variation of the benzene and indene components and subsequent functionalization.