Premium
The Nature of the Starter Unit for the Rapamycin Polyketide Synthase
Author(s) -
Lowden Philip A. S.,
Böhm Günter A.,
Staunton James,
Leadlay Peter F.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199622491
Subject(s) - polyketide synthase , polyketide , starter , atp synthase , biosynthesis , gene , chemistry , biochemistry , organism , biology , genetics , food science
A remarkably high level of incorporation is observed when 2,2,5,5‐tetradeutero ‐3,4‐ dihydroxycyclo ‐hexanecarboxylic acid is fed to the rapamycin‐producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis.