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Cyclopeptide Libraries as New Chiral Selectors in Capillary Electrophoresis
Author(s) -
Jung Günther,
Hofstetter Heike,
Feiertag Susanne,
Stoll Dieter,
Hofstetter Oliver,
Wiesmüller KarlHeinz,
Schurig Volker
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199621481
Subject(s) - capillary electrophoresis , enantiomer , chromatography , chemistry , combinatorial chemistry , amino acid , electrophoresis , computer science , stereochemistry , biochemistry
Complex libraries composed of more than five thousand cyclopeptides can act as chiral selectors when added to the mobile phase in capillary electrophoresis. Cyclo‐hexapeptide sublibraries (such as those listed below) were used to achieve baseline separations of enantiomers of N α ‐dinitrophenyl (DNP) and 9‐fluorenylmethoxycarbonyl (FMOC) amino acids and Tröger's base. This approach can be used to identify selectors for difficult‐to‐separate racemates.