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Peptide Nucleic Acids (PNAs) Containing Thymine Monomers Derived from Chiral Amino Acids: Hybridization and Solubility Properties of D ‐Lysine PNA
Author(s) -
Nielsen Peter E.,
Haaima Gerald,
Lohse Anders,
Buchardt Ole
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199619391
Subject(s) - nucleic acid , chemistry , monomer , thymine , amino acid , dna , peptide nucleic acid , lysine , peptide , solubility , oligonucleotide , stereochemistry , combinatorial chemistry , nucleobase , glycine , rna , biochemistry , organic chemistry , polymer , gene
Functionalized chiral D ‐ and L ‐amino acids in peptide nucleic acids (PNAs; backbone of a PNA shown on the right) affect their solubility properties as well as their hybridization with DNA and RNA. Mismatched base pairs are discriminated by these new PNAs better than by glycine PNAs. Monomers may find application in amide‐based combinatorial chemistry, PNAs in the pharmokinetic field and in the synthesis of DNA conjugates.