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Epothilone A and B—Novel 16‐Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution
Author(s) -
Höfle Gerhard,
Bedorf Norbert,
Steinmetz Heinrich,
Schomburg Dietmar,
Gerth Klaus,
Reichenbach Hans
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199615671
Subject(s) - epothilones , epothilone , stereochemistry , cytotoxic t cell , chemistry , cytotoxicity , microtubule , nuclear magnetic resonance spectroscopy , in vitro , biology , biochemistry , microbiology and biotechnology
How similar must a compound be to taxol in order to displace it from its binding site on microtubules? The microbial secondary metabolites epothilones A ( 1a ) and B ( 1b ) provide an answer to this question. These comparatively small, simply constructed, and highly cytotoxic macrolides surprisingly show no similarity to taxol, according to X‐ray and NMR spectroscopic results.