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A Mild General Procedure for the One‐Pot Conversion of Amides to Aldehydes
Author(s) -
Bower Shelley,
Kreutzer Kristina A.,
Buchwald Stephen L.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199615151
Subject(s) - enamine , aldehyde , hydrolysis , chemistry , organic chemistry , protocol (science) , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
A wide range of amides containing different functional groups were readily converted into their corresponding aldehydes by means of a simple protocol. The reaction with [Ti(O i Pr) 4 ] and Ph 2 SiH 2 proceeds at room temperature via an enamine intermediate, which is then hydrolyzed to afford the aldehyde [Eq (a)].
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