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Synthesis of the DNA Gyrase Inhibitor Microcin B17, a 43‐Peptide Antibiotic with Eight Aromatic Heterocycles in its Backbone
Author(s) -
Videnov Georgi,
Kaiser Dietmar,
Brooks Marc,
Jung Günther
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199615061
Subject(s) - oxazole , dna gyrase , thiazole , chemistry , antibiotics , peptide , combinatorial chemistry , stereochemistry , dna , bacteriocin , drug , biochemistry , escherichia coli , pharmacology , biology , antimicrobial , gene , organic chemistry
One of the most unusual ribosomally synthesized and posttranslationally modified polypeptides , microcin B17, is a polypeptide antibiotic (see structure below). The total synthesis of this large molecule with oxazole and thiazole rings now enables structure–activity studies in a very important field of drug targeting.