Synthesis of the DNA Gyrase Inhibitor Microcin B17, a 43‐Peptide Antibiotic with Eight Aromatic Heterocycles in its Backbone | Zendy

Videnov Georgi | Zendy; Kaiser Dietmar | Zendy; Brooks Marc | Zendy; Jung Günther | Zendy

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Synthesis of the DNA Gyrase Inhibitor Microcin B17, a 43‐Peptide Antibiotic with Eight Aromatic Heterocycles in its Backbone

Author(s) -

Videnov Georgi,

Kaiser Dietmar,

Brooks Marc,

Jung Günther

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199615061

Subject(s) - oxazole , dna gyrase , thiazole , chemistry , antibiotics , peptide , combinatorial chemistry , stereochemistry , dna , bacteriocin , drug , biochemistry , escherichia coli , pharmacology , biology , antimicrobial , gene , organic chemistry

One of the most unusual ribosomally synthesized and posttranslationally modified polypeptides , microcin B17, is a polypeptide antibiotic (see structure below). The total synthesis of this large molecule with oxazole and thiazole rings now enables structure–activity studies in a very important field of drug targeting.

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