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Template Assembled Synthetic Proteins (TASP) as Functional Mimetics of Proteins
Author(s) -
Mutter Manfred,
Dumy Pascal,
Garrouste Patrick,
Lehmann Christian,
Mathieu Marc,
Peggion Cristina,
Peluso Stéphane,
Razaname Alain,
Tuchscherer Gabriele
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199614821
Subject(s) - computational biology , chemistry , biology , microbiology and biotechnology
The bare essentials of a functional protein are all that are retained when the structural domain of a native protein is replaced by a synthetic template molecule (see picture below). New strategies for the synthesis of this novel type of template‐assembled synthetic peptide (TASP) provide functional mimetics of receptors and antibodies.