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Cover Picture (Angew. Chem. Int. Ed. Engl. 13/14/1996)
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199613581
Subject(s) - crystallography , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , hydrogen bond , lone pair , base pair , chemistry , stereochemistry , cover (algebra) , combinatorics , physics , polymer science , mathematics , molecule , dna , mechanical engineering , biochemistry , organic chemistry , engineering
The cover picture shows a ribbon model of a hairpin pyrrole/imidazole polyamide–oligonucleotide simultaneously binding the major and minor grooves of DNA (red circles: N ‐methylimidazole; blue circles: N ‐methylimidazole; blue circles: N ‐methylpyrrole rings; diamond: β‐alanine). The structural formulas on the right depict the molecular interactions responsible for sequence‐specific recognition: T · AT and C + GC base triplets are formed by Hoogstein hydrogen bonding of T to a Watson–Crick AT base pair and protonated Me C to a Watson–Crick GC base pair. On the left is the complex of the polyamide ImPyPy‐γ‐ImPyPy‐β with the site 5′‐TGACA‐3′ (circles with dots: lone pairs on N3 of purines and O2 of pyrimidines; circles containing an H: N2 hydrogen on guanine; dashed lines: putative hydrogen bonds). The energetics and specificity of the complex is reported by Szewczyk et. al. on pages 1487 ff. The picture was generated with MacDraw Pro software.