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A Steroid‐Based Cryptand for Halide Anions
Author(s) -
Davis Anthony P.,
Gilmer John F.,
Perry Justin J.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199613121
Subject(s) - cryptand , halide , chemistry , bromide , steroid , cholic acid , chloride , crown ether , fluoride , ether , organic anion , ion , medicinal chemistry , inorganic chemistry , organic chemistry , biochemistry , hormone , bile acid
As a neutral, lipophilic, purely organic host , the macrocycle 1 may deservedly be labeled an “anion‐binding counterpart” of a crown ether or cryptand. Macrocycle 1 was synthesized from the inexpensive steroid cholic acid. It forms 1:1 complexes with fluoride, chloride, and bromide and shows good discrimination in favor of the smaller anions. R = pentyl.