Premium
Self‐Complementarity of 7,9‐Dimethylguanine: A Base Pair Containing Three Hydrogen Bonds
Author(s) -
Metzger Susanne,
Lippert Bernhard
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199612281
Subject(s) - guanine , nucleobase , base pair , hydrogen bond , cytosine , chemistry , protonation , complementarity (molecular biology) , stereochemistry , dna , rna , crystallography , biochemistry , genetics , nucleotide , molecule , biology , organic chemistry , gene , ion
An unexpectedly high affinity for guanine is shown by the rare RNA nucleobase 7,9‐dimethylguanine (7,9‐DimeG). At pH 7 it forms a partially protonated homo base pair (see sketch) with its conjugated acid (7,9‐DimeGH + ), the stability of which greatly exceeds that of the Watson‐Crick base pair between guanine and cytosine.