Binuclear Lanthanide Complexes as Catalysts for the Hydrolysis of Bis( p ‐nitrophenyl)‐phosphate and Double‐Stranded DNA | Zendy

Ragunathan Kaliappa G. | Zendy; Schneider HansJörg | Zendy

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Binuclear Lanthanide Complexes as Catalysts for the Hydrolysis of Bis( p ‐nitrophenyl)‐phosphate and Double‐Stranded DNA

Author(s) -

Ragunathan Kaliappa G.,

Schneider HansJörg

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199612191

Subject(s) - phosphate , hydrolysis , catalysis , dna , chemistry , cleavage (geology) , lanthanide , plasmid , metal , phosphate buffered saline , medicinal chemistry , double stranded , stereochemistry , biochemistry , organic chemistry , biology , chromatography , ion , fracture (geology) , paleontology

The hydrolysis half‐life is reduced from 75 years to eight minutes for bis( p ‐nitrophenyl)‐phosphate (50°C, pH 7) when binuclear complexes like 1 are added; related complexes lead to similar effects. The cleavage of plasmid DNA is also accelerated dramatically. In these catalyzed reactions the distance between the metal centers plays a critical role.

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