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Efficient Regio‐ and Enantioselective Mannich Reactions
Author(s) -
Enders Dieter,
Ward David,
Adam Johannes,
Raabe Gerhard
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199609811
Subject(s) - enantioselective synthesis , enantiomer , chemistry , mannich reaction , ketone , organic chemistry , silylation , stereochemistry , combinatorial chemistry , catalysis
The readily accessible silyl ketone ( S )‐1 is an intermediate in the first practical, asymmetric Mannich reactions for the regio‐ and highly enantioselective α‐aminomethylation of ketones. The synthetically and pharmaceutically valuable Mannich bases ( R )‐ 2 are obtained in excellent yields and high enantiomeric excesses. t Hex = 1,1,2‐trimethylpropyl.