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Synthesis of Boron‐Rich Lysine Dendrimers as Protein Labels in Electron Microscopy
Author(s) -
Qualmann Britta,
Kessels Michael Manfred,
Musiol HansJürgen,
Sierralta Walter Daniel,
Jungblut Peter Wilhelm,
Moroder Luis
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199609091
Subject(s) - dendrimer , peptide , chemistry , molecule , electron microscope , boron , lysine , amino acid , nanotechnology , combinatorial chemistry , biophysics , crystallography , biochemistry , materials science , organic chemistry , biology , physics , optics
A novel approach from dendrimer chemistry for the synthesis of marker molecules containing eight carboranyl amino acids (MeCBA) (see structure on the right) overcomes the known inconveniences in the syntheses of linear peptide constructs. Marker molecules of this type should be able to be used in electron microscopy. R = protected peptide terminus.