Copper( I )‐Promoted Stille Cross‐Coupling of Stannyl Enol Ethers with Enol Triflates: Construction of Complex Polyether Frameworks | Zendy

Nicolaou K. C. | Zendy; Sato Mitsunobu | Zendy; Miller Neil D. | Zendy; Gunzner Janet L. | Zendy; Renaud Johanne | Zendy; Untersteller Edouard | Zendy

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Copper( I )‐Promoted Stille Cross‐Coupling of Stannyl Enol Ethers with Enol Triflates: Construction of Complex Polyether Frameworks

Author(s) -

Nicolaou K. C.,

Sato Mitsunobu,

Miller Neil D.,

Gunzner Janet L.,

Renaud Johanne,

Untersteller Edouard

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199608891

Subject(s) - stille reaction , enol , copper , coupling (piping) , chemistry , enol ether , polymer chemistry , organic chemistry , materials science , polymer , catalysis , composite material

A simple and efficient route to bistetrahydropyranyl systems like 1 relies on the coupling of a stannyl enol ether with an enol triflate in the presence of a catalytic amount of [Pd(PPh 3 ) 4 ] and excess amounts of CuCl and K 2 CO 3 . Complex polyether structures are also accessible in good yields, as the synthesis of a structural element of maitotoxin demonstrates.

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