z-logo
Premium
Formation of Stable DNA Loops by Incorporation of Nonpolar, Non‐Hydrogen‐Bonding Nucleoside Isosteres
Author(s) -
Ren XiaoFeng,
Schweitzer Barbara A.,
Sheils Charles J.,
Kool Eric T.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199607431
Subject(s) - nucleoside , oligonucleotide , duplex (building) , thymidine , deoxyadenosine , hydrogen bond , chemistry , stereochemistry , dna , nucleotide , nucleic acid , loop (graph theory) , combinatorial chemistry , molecule , biochemistry , organic chemistry , gene , mathematics , combinatorics
The stability of hairpin structures formed from oligonucleotides depends on the units in the loop region. When the nonpolar nucleoside isosteres 1 – 3 replace the natural nucleosides thymidine and deoxyadenosine in the loop linking two octanucleotides, the corresponding duplex DNAs are considerably more stable than the natural analogues.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here