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Formation of Stable DNA Loops by Incorporation of Nonpolar, Non‐Hydrogen‐Bonding Nucleoside Isosteres
Author(s) -
Ren XiaoFeng,
Schweitzer Barbara A.,
Sheils Charles J.,
Kool Eric T.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199607431
Subject(s) - nucleoside , oligonucleotide , duplex (building) , thymidine , deoxyadenosine , hydrogen bond , chemistry , stereochemistry , dna , nucleotide , nucleic acid , loop (graph theory) , combinatorial chemistry , molecule , biochemistry , organic chemistry , gene , mathematics , combinatorics
The stability of hairpin structures formed from oligonucleotides depends on the units in the loop region. When the nonpolar nucleoside isosteres 1 – 3 replace the natural nucleosides thymidine and deoxyadenosine in the loop linking two octanucleotides, the corresponding duplex DNAs are considerably more stable than the natural analogues.