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Continuous Asymmetric Synthesis in a Membrane Reactor
Author(s) -
Kragl Udo,
Dreisbach Claus
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199606421
Subject(s) - benzaldehyde , diethylzinc , membrane reactor , membrane , decoupling (probability) , ultrafiltration (renal) , chemistry , catalysis , chemical engineering , chromatography , organic chemistry , enantioselective synthesis , biochemistry , control engineering , engineering
Adapted from biocatalytic reactions the principle of the membrane reactor (represented schematically on the right) is applicable to the continuous asymmetric addition of diethylzinc to benzaldehyde. α,α‐Diphenyl‐ L ‐prolinol is coupled to a homogeneously soluble polymer ( 1 ), which enables it to be retained in the reaction vessel by an ultrafiltration membrane. By decoupling the residence time of reactants and the catalyst the total turnover number could be increased by a factor of 10.