Solid‐Phase, Parallel Syntheses by Ugi Multicomponent Condensation | Zendy

Tempest Paul A. | Zendy; Brown S. David | Zendy; Armstrong Robert W. | Zendy

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Solid‐Phase, Parallel Syntheses by Ugi Multicomponent Condensation

Author(s) -

Tempest Paul A.,

Brown S. David,

Armstrong Robert W.

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199606401

Subject(s) - isocyanide , aryl , alkyl , condensation , ugi reaction , chemistry , amino acid , organic chemistry , combinatorial chemistry , condensation reaction , catalysis , biochemistry , physics , thermodynamics

The number and availability of starting compounds determine the structure diversity possible in a multicomponent reaction. For example, in a set of parallel reactions an amino‐functionalized resin (P) was treated with 8 aldehydes, 12 carboxylic acids, and 1 isocyanide to provide 88 of the desired α‐acyl amino amides [Eq. (a)]. Additional isocyanides not available commercially can be prepared from α‐lithiated benzylisonitrile and used without purification. R 1 , R 2 = alkyl, aryl.

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