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Solid‐Phase, Parallel Syntheses by Ugi Multicomponent Condensation
Author(s) -
Tempest Paul A.,
Brown S. David,
Armstrong Robert W.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199606401
Subject(s) - isocyanide , aryl , alkyl , condensation , ugi reaction , chemistry , amino acid , organic chemistry , combinatorial chemistry , condensation reaction , catalysis , biochemistry , physics , thermodynamics
The number and availability of starting compounds determine the structure diversity possible in a multicomponent reaction. For example, in a set of parallel reactions an amino‐functionalized resin (P) was treated with 8 aldehydes, 12 carboxylic acids, and 1 isocyanide to provide 88 of the desired α‐acyl amino amides [Eq. (a)]. Additional isocyanides not available commercially can be prepared from α‐lithiated benzylisonitrile and used without purification. R 1 , R 2 = alkyl, aryl.