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Synthesis of Flavin‐Containing Model Compounds for DNA Photolyase Mediated DNA Repair
Author(s) -
Carell Thomas,
Epple Robert,
Gramlich Volker
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199606201
Subject(s) - photolyase , pyrimidine dimer , chemistry , moiety , dna , cyclobutane , uracil , dna repair , cleavage (geology) , photochemistry , flavin group , dna damage , dimer , stereochemistry , biochemistry , biology , enzyme , organic chemistry , ring (chemistry) , paleontology , fracture (geology)
Irradiation with white light or monochromatic light at 366 nm causes the cleavage of the uracil dimer 1 at the cyclobutane moiety, providing that the flexin units are reduced prior to the reaction. This cleavage reaction of model compounds such as 1 forms the basis of DNA photolyase mediated DNA repair.