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Sibyllimycine, 5,6,7,8‐Tetrahydro‐3‐methyl‐8‐oxo‐4‐azaindolizidine, a Novel Metabolite from Thermoactinomyces sp.
Author(s) -
Hafenbradl Doris,
Keller Martin,
Stetter Karl O.,
Hammann Peter,
Hoyer Frank,
Kogler Herbert
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199605451
Subject(s) - metabolite , fermentation , natural product , chemistry , thermophile , actinomyces , stereochemistry , biology , organic chemistry , biochemistry , bacteria , paleontology , enzyme
The first natural product of its structure type , azaindolizidine 1 was produced by fermentation of an isolate of thermophilic actinomyces obtained from a 60°C hot spring at Lake Tanganyika (Africa). The structure of this compound was determined from NMR data and verified by synthesis from methylimidazole and 4‐bromobutyronitrile.