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The “Magic” Diarylhydroxymethyl Group
Author(s) -
Braun Manfred
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199605191
Subject(s) - stereocenter , geminal , deprotonation , stereoselectivity , group (periodic table) , aryl , chemistry , catalysis , stereochemistry , magic (telescope) , schematic , metal , enantioselective synthesis , physics , organic chemistry , quantum mechanics , ion , alkyl , electronic engineering , engineering
Increasing stereoselectivity in numerous recently developed methods of asymmetric synthesis is possible with the diarylhydroxymethyl group, which is typically employed in deprotonated form as a ligand in metal complexes. In the transition state of these reactions the geminal aryl groups are apparently fixed in a chiral conformation owing to the influence of a permanent stereogenic center X * . A schematic representation of this type of metal catalyst is shown on the right.