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A Versatile New Preparation of Cyclopropylamines from Acid Dialkylamides
Author(s) -
Chaplinski Vladimir,
de Meijere Armin
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199604131
Subject(s) - stoichiometry , tetra , chemistry , titanium , combinatorial chemistry , organic chemistry , medicinal chemistry
The reaction of acid N,N ‐dialkylamides with alkylmagnesium bromides in the presence of a stoichiometric amount of titanium tetra(2‐propanolate) produces dialkylcyclopropylamines like 1 and 2 in moderate to good yields. Previously inaccessible aminocyclopropane derivatives are now readily available.