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Cover Picture (Angew. Chem. Int. Ed. Engl. 4/1996)
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199603531
Subject(s) - cover (algebra) , chemistry , ligand (biochemistry) , stereochemistry , computer science , engineering , receptor , mechanical engineering , biochemistry
The cover picture shows the catalytic asymmetric aminohydroxylation (AA) of alkenes in action. Methyl cinnamate can be transformed directly into a derivative of the taxol side chain with the catalyst system K 2 OsO 2 (OH) 4 and a phthalazine ligand; Chloramine T serves as the nitrenoid source. Either enantiomer can be produced at will by selection of the appropriate ligand. The asymmetric aminohydroxylation (AA) follows the development of the asymmetric epoxidation (AE) and the asymmetric dihydroxylation (AD)—three reactions whose importance for organic synthesis cannot be overstated. Li, Chang, and Sharpless report more on the new catalytic AA on p. 451 ff. (The cover picture was created by Michael E. Pique, The Scripps Research Institute, La Jolla, CA, USA.)