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(15 R )‐16‐ m ‐Tolyl‐17,18,19,20‐tetranorisocarbacyclin: A Stable Ligand with High Binding Affinity and Selectivity for a Prostacyclin Receptor in the Central Nervous System
Author(s) -
Suzuki Masaaki,
Kato Koichi,
Noyori Ryoji,
Watanabe Yumiko,
Takechi Hajime,
Matsumura Kiyoshi,
Långström Bengt,
Watanabe Yasuyoshi
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199603341
Subject(s) - prostacyclin , agonist , central nervous system , chemistry , ligand (biochemistry) , receptor , biophysics , binding site , selectivity , iloprost , biochemistry , endocrinology , biology , catalysis
Structural modification of the prostacyclin agonist isocarbacyclin resulted in the stable, highly selective ligand 1 , which displays high binding affinity for a prostacyclin receptor in the central nervous system. The binding profile of 1 thus contrasts markedly with those of cicaprost and iloprost.