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Cover Picture (Angew. Chem. Int. Ed. Engl. 3/1996)
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199602291
Subject(s) - selectin , cover (algebra) , chemistry , glycoprotein , tetrasaccharide , int , computational biology , computer science , biochemistry , adhesion , biology , programming language , engineering , mechanical engineering , polysaccharide , organic chemistry
The cover picture shows schematically how leukocytes from the blood stream bind to activated endothelium during inflammation processes and are finally extravasated into the surrounding tissue. The first step is the interaction of glycoproteins on leukocytes with adhesion molecules on the endothelium (P‐, E‐selectin). The tetrasaccharide sialyl Lewis x has been identified as the binding epitope in complex glycoproteins, which are bound through carbohydrates to the selectins. Trivalent glycopeptides like that in the middle of the picture, which present three sialyl Lewis x units, were synthesized by H. Kunz et al. with the goal of achieving improved receptor affinity. The authors describe the results of the adhesion tests and the synthesis of the glycopeptides on pages 321 – 324.