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Synthesis of the Nonamannan Residue of a Glycoprotein with High Mannose Content
Author(s) -
Grice Peter,
Ley Steven V.,
Pietruszka Jörg,
Priepke Henning W. M.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199601971
Subject(s) - glycoprotein , linker , disaccharide , mannose , human immunodeficiency virus (hiv) , chemistry , glycosyl , residue (chemistry) , glycosylation , in vitro , viral envelope , biochemistry , stereochemistry , combinatorial chemistry , virology , biology , computer science , operating system
Deliberate tuning of the reactivity of the appropriate glycosyl donors enables nonamannan 1 to be prepared efficiently in a concise manner. Bound through a disaccharide linker, 1 is a major constituent of the envelope glycoprotein gp120 of the human‐immunodeficiency virus (HIV). Gp120 plays an important role in the attachment to and penetration of target cells by HIV and in the antiviral response.