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Acyclic Stereocontrol in Radical Reactions: ρ‐Selectivity with Oxazolidinone Auxiliories
Author(s) -
Sibi Mukund P.,
Ji Jianguo
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199601901
Subject(s) - chemistry , lewis acids and bases , selectivity , ring (chemistry) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
It's the addition of Lewis acids that does it! Reaction (a) proceeds with diastereoselectivities ≥ 100:1 if the radical transfer takes place in the presence of Lewis acids such as MgI 2 , MgBr 2 , or Sc(OTf) 3 . The influence of the substituents at position 4 of the oxazolidinone ring on the allylation was also studied.