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Synthesis of Chiral 1,1′‐Iminodicarboxylic Acid Derivatives from α‐Amino Acids, Aldehydes, Isocyanides, and Alcohols by the Diastereoselective Five‐Center–Four‐Component Reaction
Author(s) -
Demharter Anton,
Hörl Werner,
Herdtweck Eberhardt,
Ugi Ivar
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199601731
Subject(s) - diastereomer , chemistry , component (thermodynamics) , organic chemistry , amino acid , reaction conditions , ugi reaction , combinatorial chemistry , catalysis , isocyanide , biochemistry , physics , thermodynamics
Not only yields of up to 98% but also diastereomeric excesses of up to 84% are the advantages of this effective and versatile multicomponent reaction for the synthesis of iminodicarboxylic acid derivatives in a one‐pot reaction [Eq. (a)].