Synthesis of Chiral 1,1′‐Iminodicarboxylic Acid Derivatives from α‐Amino Acids, Aldehydes, Isocyanides, and Alcohols by the Diastereoselective Five‐Center–Four‐Component Reaction | Zendy

Demharter Anton | Zendy; Hörl Werner | Zendy; Herdtweck Eberhardt | Zendy; Ugi Ivar | Zendy

Premium

Synthesis of Chiral 1,1′‐Iminodicarboxylic Acid Derivatives from α‐Amino Acids, Aldehydes, Isocyanides, and Alcohols by the Diastereoselective Five‐Center–Four‐Component Reaction

Author(s) -

Demharter Anton,

Hörl Werner,

Herdtweck Eberhardt,

Ugi Ivar

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199601731

Subject(s) - diastereomer , chemistry , component (thermodynamics) , organic chemistry , amino acid , reaction conditions , ugi reaction , combinatorial chemistry , catalysis , isocyanide , biochemistry , physics , thermodynamics

Not only yields of up to 98% but also diastereomeric excesses of up to 84% are the advantages of this effective and versatile multicomponent reaction for the synthesis of iminodicarboxylic acid derivatives in a one‐pot reaction [Eq. (a)].

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research