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New, Efficient Routes to Cyclic Enediynes
Author(s) -
König Burkhard
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199601651
Subject(s) - intramolecular force , enediyne , combinatorial chemistry , chemistry , sequence (biology) , carbenoid , stereochemistry , organic chemistry , catalysis , rhodium , biochemistry
The search for simple and pharmacologically active enediynes should be considerably facilitated by a new sequence leading to acyclic and also cyclic enediynes, which proceeds via a carbenoid intermediate. The recently reported intramolecular variant yields functionalized enediynes on a multigram scale from readily accessible starting materials in yields of up to 95%.
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