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Enzymatic Synthesis of Peptides and Ras Lipopeptides Employing Choline Ester as a Solubilizing, Protecting, and Activating Group
Author(s) -
Schelhaas Michael,
Glomsda Simone,
Hänsler Marion,
Jakubke HansDieter,
Waldmann Herbert
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199601061
Subject(s) - choline , enzyme , esterase , protecting group , chemistry , biochemistry , peptide , organic chemistry , alkyl
Since it can be removed under extremely mild conditions and with complete selectivity by choline esterase, the solubilizing choline ester function is advantageous for high‐yielding peptide syntheses. This enzyme‐labile protecting group was employed in the synthesis of the S‐palmitoylated and S‐farnesylated C‐terminal lipohexapeptide of the human N‐ Ras protein.