On Ligand Design for Catalytic Outer Sphere Reactions: A Simple Asymmetric Synthesis of Vinylglycinol | Zendy

Trost Barry M. | Zendy; Bunt Richard C. | Zendy

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On Ligand Design for Catalytic Outer Sphere Reactions: A Simple Asymmetric Synthesis of Vinylglycinol

Author(s) -

Trost Barry M.,

Bunt Richard C.

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199600991

Subject(s) - ligand (biochemistry) , catalysis , chiral ligand , enantiomer , block (permutation group theory) , simple (philosophy) , combinatorial chemistry , enantioselective synthesis , chemistry , stereochemistry , computational chemistry , mathematics , organic chemistry , geometry , biochemistry , philosophy , receptor , epistemology

A quantitative synthesis with an enantiomeric ratio of 99:1 has been achieved for the important building block vinylglycinol. The crucial concept lay in sculpting the chiral pocket in catalyst 1 by restricting bond rotations in its chiral‐inducing ligand.

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