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On Ligand Design for Catalytic Outer Sphere Reactions: A Simple Asymmetric Synthesis of Vinylglycinol
Author(s) -
Trost Barry M.,
Bunt Richard C.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199600991
Subject(s) - ligand (biochemistry) , catalysis , chiral ligand , enantiomer , block (permutation group theory) , simple (philosophy) , combinatorial chemistry , enantioselective synthesis , chemistry , stereochemistry , computational chemistry , mathematics , organic chemistry , geometry , biochemistry , philosophy , receptor , epistemology
A quantitative synthesis with an enantiomeric ratio of 99:1 has been achieved for the important building block vinylglycinol. The crucial concept lay in sculpting the chiral pocket in catalyst 1 by restricting bond rotations in its chiral‐inducing ligand.