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β,β‐Dimethylcyclolanthionines, New Constrained Dipeptide Mimetics: Synthesis, Crystal Structures, and Conformational Studies
Author(s) -
Shao Hui,
Lee ChangWoo,
Zhu Qin,
Gantzel Peter,
Goodman Murray
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199600901
Subject(s) - dipeptide , lanthionine , peptidomimetic , disulfide bond , cysteine , chemistry , stereochemistry , peptide , combinatorial chemistry , biochemistry , enzyme
The labile disulfide bridge between cysteine residues in naturally occurring peptides can be replaced by lanthionine, as demonstrated by the synthesis of conformation‐ally constrained dipeptide mimetics (see below) based on β,β‐dimethylcyclolanthio‐nines. Their structural features indicate that they represent a novel family of peptidomimetics.