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A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug‐Resistance Reversing Activity
Author(s) -
Ghosh Arun K.,
Liu Wenming,
Xu Yibo,
Chen Zhidong
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199600741
Subject(s) - reversing , multiple drug resistance , enantioselective synthesis , drug resistance , reversion , pharmacology , drug , stereochemistry , medicine , chemistry , biology , biochemistry , materials science , genetics , gene , composite material , phenotype , catalysis
Tumor cells can develop resistance towards the drugs administered in chemotherapy . Hapalosin ( 1 , R H), a cyclodepsipeptide whose total synthesis has now been achieved, can inhibit this resistance. The constitution and configuration of the compound have been confirmed by its synthesis. It should now be possible to carry out detailed structure–function studies.