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“New” Reagents for the “Old” Pinacol Coupling Reaction
Author(s) -
Wirth Thomas
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199600611
Subject(s) - pinacol , reagent , combinatorial chemistry , coupling (piping) , chemistry , coupling reaction , natural product , organic chemistry , catalysis , materials science , metallurgy
Even 130 years after its discovery , the pinacol coupling [Eq. (a)] still has plenty of new variants. New reagents have been developed that are suitable not only for the elegant synthesis of 1,2‐diols but also for the formation of amino alcohols. This powerful reaction has been used in numerous natural product syntheses.