A Strategy of “Random Glycosylation” for the Production of Oligosaccharide Libraries | Zendy

Kanie Osamu | Zendy; Barresi Frank | Zendy; Ding Yili | Zendy; Labbe Jill | Zendy; Otter Albin | Zendy; Forsberg L. Scott | Zendy; Ernst Beat | Zendy; Hindsgaul Ole | Zendy

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A Strategy of “Random Glycosylation” for the Production of Oligosaccharide Libraries

Author(s) -

Kanie Osamu,

Barresi Frank,

Ding Yili,

Labbe Jill,

Otter Albin,

Forsberg L. Scott,

Ernst Beat,

Hindsgaul Ole

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199527201

Subject(s) - glycosylation , oligosaccharide , chemistry , stereochemistry , organic chemistry , biochemistry

Six at one blow! The creation of small oligosaccharide libraries was achieved by a new strategy of random glycosylation of nonprotected sugars. With tri‐ O ‐benzyl‐ L ‐fucopyranosyl trichloroacetimidate as donor and βGal(1 → n )βGlcNAcOR ( n = 3, 4, 6; R = (CH 2 ) 8 OC 6 H 4 ‐ p ‐OMe) as acceptors, all six trisaccharides form in DMF in roughly equal quantities. It is astounding that all free OH groups are fucosylated at a similar rate.

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