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Regio‐ and Diastereoselective Synthesis of β‐Amino Ketones by Addition of Imines to Iminium Salts
Author(s) -
Arend Michael,
Risch Nikolaus
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199526391
Subject(s) - iminium , regioselectivity , chemistry , mannich reaction , combinatorial chemistry , organic chemistry , surface modification , catalysis
High regioselectivity, good yields, and mild reaction conditions are the advantages of the reaction of iminium salts 1 with imines 2 to afford the Mannich bases 3 . Since the amino group in 3 can be substituted readily, this approach enables the simple regioselective functionalization of ketones—an important goal in synthesis.