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A Dinuclear (μ‐Carboxylato)manganese( II ) Complex Derived from a Macrocyclic Ligand: A Structural Model for Active Sites in Natural Systems
Author(s) -
Adams Harry,
Bailey Neil A.,
Debaecker Noele,
Fenton David E.,
Kanda Wakako,
Latour JeanMarc,
Okawa Hisashi,
Sakiyama Hiroshi
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199525351
Subject(s) - manganese , carboxylate , chemistry , isomerase , electron paramagnetic resonance , stereochemistry , ligand (biochemistry) , active site , metal , residue (chemistry) , active center , enzyme , crystallography , biochemistry , organic chemistry , physics , receptor , nuclear magnetic resonance
Even in solution only a single μ‐carboxylato bridge links the metal centers in complex 1 , according to EPR studies. This feature makes the complex an interesting structural model for the active center in enzymes that contain two manganese atoms. In D ‐xylose isomerase, for example, the manganese atoms are linked by a single bridging carboxylate(glutamate) residue.