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Hydrolysis of a Phosphate Diester Doubly Coordinated to a Dinuclear Cobalt( III ) Complex: A Novel Mechanism
Author(s) -
Wah Daphne,
Lebuis AnneMarie,
Chin Jik
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199524121
Subject(s) - hydrolysis , phosphate , chemistry , nucleophile , cobalt , ligand (biochemistry) , metal , bridging (networking) , bridging ligand , stereochemistry , inorganic chemistry , combinatorial chemistry , organic chemistry , catalysis , receptor , biochemistry , computer network , computer science
Nucleophilic attack of the bridging oxo ligand is the key step in the hydrolysis of the bridging phosphate diester in complex 1 . This hydrolysis is 10 12 times faster than the hydrolysis of the free phosphate diester. Thus, the phosphate‐free Co complex is an interesting model of enzymes having two metal atoms in the active site.