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Asymmetrization of meso 1,4‐Enediol Ethers by Isomerization with a Chiral binap–Rh I Catalyst
Author(s) -
Hiroya Kou,
Kurihara Yuko,
Ogasawara Kunio
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199522871
Subject(s) - isomerization , binap , catalysis , chemistry , medicinal chemistry , organic chemistry , enantioselective synthesis
High enantiomeric purities are achieved with the method described here for the transformation of meso 1,4‐enediol ethers such as 1 into oxyketones such as 2 in the presence of a chiral Rh I catalyst. These products are versatile chiral building blocks in synthesis. TBS = tert ‐butyldimethylsilyl.
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