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Antibody‐Catalyzed Phosphate Triester Hydrolysis
Author(s) -
Rosenblum Jonathan S.,
Lo LeeChiang,
Li Tingyu,
Janda Kim D.,
Lerner Richard A.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199522751
Subject(s) - hapten , hydrolysis , prodrug , chemistry , phosphate , catalysis , amine gas treating , antibody , combinatorial chemistry , organic chemistry , biochemistry , biology , immunology
Not geometric but electrostatic features of the transition state serve as a paradigm for the design of antibodies that catalyze the hydrolysis of phosphate triesters. Thus, an efficient catalytic antibody was obtained with the dipolar amine oxide 1 as hapten. Potential applications of such antibodies include activation of prodrugs, disposal of insecticides, and counteraction of the toxicity of chemical warfare agents.