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The β‐Lactam‐Nucleoside Chimera
Author(s) -
Dömling Alexander,
Starnecker Manfred,
Ugi Ivar
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199522381
Subject(s) - isocyanide , nucleoside , aldehyde , lactam , chemistry , ugi reaction , chimera (genetics) , stereochemistry , antibiotics , combinatorial chemistry , biochemistry , catalysis , gene
Potential antiviral agents or antibiotics such as 1 are described herein. They consist of a nucleoside portion and a β‐lactam portion and can be prepared in a one‐pot reaction by the Ugi reaction from a β‐amino acid, an aldehyde, and an isocyanide.