N ‐Hydroxypyridinethiones as Photochemical Hydroxyl Radical Sources for Oxidative DNA Damage | Zendy

Adam Waldemar | Zendy; Ballmaier Daniel | Zendy; Epe Bernd | Zendy; Grimm Günther N. | Zendy; SahaMöller Chantu R. | Zendy

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N ‐Hydroxypyridinethiones as Photochemical Hydroxyl Radical Sources for Oxidative DNA Damage

Author(s) -

Adam Waldemar,

Ballmaier Daniel,

Epe Bernd,

Grimm Günther N.,

SahaMöller Chantu R.

Publication year - 1995

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199521561

Subject(s) - radical , chemistry , dna , hydroxyl radical , dna damage , photochemistry , oxidative phosphorylation , oxidative damage , reagent , irradiation , oxidative stress , biochemistry , organic chemistry , physics , nuclear physics

On irradiation with UV light (λ = 350 nm) the N ‐hydroxypridinethiones 1 and 2 generate hydroxyl radicals, which cause single‐strand breaks and base modifications in calf thymus DNA and superhelical PM2 DNA. The para isomer 2 is significantly more genotoxic than the known antibacterial and fungicidal reagent pyridinethione 1 .

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