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N ‐Hydroxypyridinethiones as Photochemical Hydroxyl Radical Sources for Oxidative DNA Damage
Author(s) -
Adam Waldemar,
Ballmaier Daniel,
Epe Bernd,
Grimm Günther N.,
SahaMöller Chantu R.
Publication year - 1995
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199521561
Subject(s) - radical , chemistry , dna , hydroxyl radical , dna damage , photochemistry , oxidative phosphorylation , oxidative damage , reagent , irradiation , oxidative stress , biochemistry , organic chemistry , physics , nuclear physics
On irradiation with UV light (λ = 350 nm) the N ‐hydroxypridinethiones 1 and 2 generate hydroxyl radicals, which cause single‐strand breaks and base modifications in calf thymus DNA and superhelical PM2 DNA. The para isomer 2 is significantly more genotoxic than the known antibacterial and fungicidal reagent pyridinethione 1 .